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KMID : 1123920100240030430
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Korean Journal of Oriental Physiology and Pathology
2010 Volume.24 No. 3 p.430 ~ p.438
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Effect of Sihogayonggolmoryeotanghabcheongsimyeonjaemgagambang on Hypertension in Spontaneous Hypertensive Rats
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Lee Sung-Jong
An Joung-Jo
Cho Hyun-Kyoung
Yoo Ho-Rhyong
Seol In-Chan
Kim Yoon-Sik
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Abstract
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This study was done to investigate the effect of SHCG on hypertension in spontaneous hypertensive rats. SHR was sensitized and challenged with Sihogayonggolmoryeotanghabcheongsimyeonjaemgagambang (SHCG) for 4 weeks. The 3 groups have 6 rats, respectively. Experimental group was treated with 56.7 mg/kg of SHCG orally and control group was treated with 56.7 mg/kg of normal saline instead. SHCG significantly showed safety against cytotoxicity on hFCs and toxicity in the liver. SHCG significantly decreased the blood pressure and the heart rate. SHCG significantly decreased the levels of aldosterone. SHCG significantly decreased the levels of dopamine, norepinephrine, and epinephrine. SHCG significantly decreased the levels of potassium and chloride. SHCG significantly decreased the levels of uric acid and creatinine. These results suggest that SHCG might be hopeful in treatment of hypertension.
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KEYWORD
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Sihogayonggolmoryeotanghabcheongsimyeonjaemgagambang(SHCG), hypertension, spontaneous hypertensive rats
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